Due to large differences in human lifestyles, including diet type, consumption of alcohol and amount of exercise among others, individual-to-individual differences between different human subjects are often high, requiring a huge number of subjects in conventional clinical trials to achieve statistical significance. However, Alimetrics has resolved this problem by profiling a large number of subjects for health-related parameters and GI tract well-being and microbiota. In the targeted clinical trial set-up, valid individuals for each trial are first preselected from Alimetrics’s database. Each individual then acts as his or her own control in a balanced cross-over experimental design. Careful selection of sampling points and analysis strategy combined with innovative statistical modelling provides significant results with only tens of subjects. Consequently, the clinical trials provided by Alimetrics are rapid and cost-effective.

Alimetrics manages the complete clinical trial package:

• Application and arrangements for Ethical Committee approval
• Optimisation of the trial design and number of replicates to effectively answer the anticipated question
• Recruitment of subjects (healthy and/or compromised)
• Selection of the most relevant clinical parameters amongst over one hundred clinical parameters from serum, urine and faeces that Alimetrics is capable of measuring
• Analysis of the selected parameters
• Data management, statistical analyses and mathematical modelling
• Final report and marketing material

Alimetrics also serves its clients by providing parts of the complete package, e.g. by analysing clinical parameters from clinical trials arranged by the client.

Examples:

• Low glycaemic index products
• Products to normalise intestinal function with patients suffering from coeliac disease
• Cholesterol absorption
• Effects of diet change on intestinal microbial community